Monurol, Treatment for Urine Infection

Monurol contains an antibiotic called fosfomycin, which is widely used to treat urinary infections in women.
Monurol, Treatment for Urine Infection

Last update: 09 February, 2023

Monurol sachets contain fosfomycin, an antibiotic that is indicated for the treatment of urinary infection or acute uncomplicated cystitis caused by microorganisms sensitive to fosfomycin. It is also indicated for the prevention of urinary tract infections after a surgical intervention.

Being an antibiotic, it’s subject to medical prescription, and pharmacies should only dispense it through a prescription.

Monurol is a very effective drug for women who have a urine infection, as it’s a broad spectrum antibiotic. And what does this mean? Well, it’s able to act against different types of bacteria.

How should Monurol be taken?

There are two presentations of Monurol with different doses:

  • 2 g sachets: suitable for girls between 6 and 11 years old.
  • 3 g sachets: indicated for adolescents over 12 years of age and adult women.

Monurol is always sold in sachets. The content should be poured into half a glass of water, stirred until it dissolves, and then ingested immediately.

Monurol medication.

The administration of Monurol is very easy, since the most common prescription is usually a single dose. It’s recommended to take the drug on an empty stomach, preferably before going to bed and with an empty bladder.

The clinical symptoms generally disappear 2 or 3 days after the end of the treatment. The persistence of some local symptoms isn’t necessarily a sign of therapeutic failure, but may be due to previous inflammation.

Like most drugs, there are groups of people for whom the administration of Monurol is contraindicated, and therefore, you should not take it if:

  • You have any known hypersensitivity or allergy to the active substance or to any of the excipients of the medicine
  • You have kidney failure
  • You’re on hemodialysis
  • You’re under 6 years old

If I am taking other medications, can I take Monurol?

In general, this drug doesn’t have particularly serious interactions with other drugs, although we want to mention two cases which deserve special consideration:

  • Simultaneous administration of this drug with metoclopramide, as well as other drugs that increase gastrointestinal motility, may reduce the effect of the antibiotic.
  • If you are taking anticoagulant therapy, such as the well-known Sintrom, you should consult your doctor before administering it together with Monurol, as it could enhance its effect.

Other considerations

Some pills.

This medicine contains sucrose. If your doctor has told you that you have an intolerance to some sugars or you are diabetic, contact them before taking this medicine.

Possible adverse reactions

If you are allergic to the antibiotic or any of its excipients, a hypersensitivity reaction may occur, including anaphylaxis and anaphylactic shock. If it occurs, treatment with fosfomycin should be discontinued and appropriate medical treatment started.

A characteristic of antibiotics is that they also act against other bacteria that have a role to play in our bodies. For this reason, diarrhea, of different severity, is frequent when taking antibiotics.

In the event of severe, persistent or bloody diarrhea during or after treatment with this medicine (even several weeks after treatment), the doctor should be informed.

Other common adverse reactions are:

Other less common side effects are:

  • Vomiting
  • Abdominal pain
  • Skin rash
  • Itching (pruritus)

Warnings and cautions

A pregnant woman.
  • Although the studies that have been carried out so far don’t show reproductive toxicity, the use of Monurol in pregnant patients is not suitable.
  • The decision to take this medicine in lactating women is the doctor’s to make, who will assess the benefits against risk.
  • Driving and using machines: Although, in principle, there should be no problem, it’s true that some cases of dizziness have been described, so caution should be exercised in these cases.

4 tips to use Monurol well

  1. For this antibiotic to work best, we should take it on an empty stomach, which implies at least one hour after eating, preferably 2 or 3.
  2. We also increase the effectiveness if we take the medicine at night before sleeping, and just after having emptied the bladder. In this way we’ll ensure that the medicine remains in the urine for longer after administration.
  3. Important! You mustn’t resort to it indiscriminately. It’s a very effective drug, but you must be aware that misuse will increase resistance to the antibiotic and it will no longer be as effective. Therefore, it should always be prescribed by a doctor.
  4. If you have a relapse after days or weeks, this antibiotic is probably not suitable for treating the causative bacteria, and you’ll have to change to another antibiotic (many bacteria cause a urine infection, and not all antibiotics are effective against all of them).

  • Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). (n.d.). FICHA TÉCNICA MONUROL. Retrieved from

  • G.M., K. (2013). Fosfomycin trometamol: A review of its use as a single-dose oral treatment for patients with acute lower urinary tract infections and pregnant women with asymptomatic bacteriuria. Drugs.

  • Zhanel, G. G., Walkty, A. J., & Karlowsky, J. A. (2016). Fosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis. Canadian Journal of Infectious Diseases and Medical Microbiology.

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